In November 2020 the Food and Drug Administration (FDA) reported reactions in patients with dermal filler following the first dose of the vaccination. The reaction in all three cases was swelling, the FDA classified this as medically significant but not a serious adverse event.
Filler related reactions have only been reported in the Moderna mRNA vaccine trial. The three patients all reported swelling following their first vaccine . Two reported facial swelling 1 and 2 days after vaccine and the third lip angioedema 2 days following vaccine. One of the patients had a similar reaction following a flu vaccine in the past, in all cases the swelling resolved.
Delayed dermal filler inflammatory responses are a rare occurrence with hyaluronic acid fillers and reactions may be prompted by viral and bacterial infections, influenza vaccines and dental treatments. These events are rare and transitory and respond well to corticosteroids.
With this in mind patients who have had dermal filler treatments should not refuse or be refused vaccination for this reason, and patients who have had the vaccine are not excluded from having dermal fillers in the future.
While these reactions were reported specifically within the Moderna mRNA vaccine trial, it does not suggest that similar reactions could not occur following other manufactures covid 19 vaccines.